The HA delivery challenge
Hyaluronic acid (HA) is a naturally occurring glycopolymer present in multiple tissues of the body—including skin, eyes, joints, and mucosa—required to maintain tissue health and function. Advancing age, disease or injury can result in a deficiency of HA. While levels can be replenished through administration of exogenous HA, this presents delivery and retention challenges. Because the large size of HA prevents passive delivery into tissues like skin, delivery can only be accomplished with injection. In addition, exogenous HA must be chemically stabilized to prevent rapid degradation by enzymes within target tissues.